Talk:Modafinil
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I have added a few minor details, broadening the scope of the article. I would be interested if anyone knows the time for modafinil to take effect after ingestion. Richard Farmbrough.
- Pretty much the standard 35-45min as with most ingested drugs. From the PDR monograph: "Absorption of PROVIGIL tablets is rapid, with peak plasma concentrations occurring at 2-4 hours. The bioavailability of PROVIGIL tablets is approximately equal to that of an aqueous suspension. The absolute oral bioavailability was not determined due to the aqueous insolubility (<1 mg/mL) of modafinil, which precluded intravenous administration. Food has no effect on overall PROVIGIL bioavailability; however, its absorption (t max ) may be delayed by approximately one hour if taken with food." (copyrighted, fair use, don't include in article) --Bk0 20:22, 21 Dec 2004 (UTC)
Military Use
Many sites refer to military use, some hard and fast documentation would be nice. Rich Farmbrough 13:46, 18 Aug 2004 (UTC)
"Dosage varies from once 100 mg/day to twice 200 mg per day (the second about 4 hours after waking), and is more effective on naive users."
This seems more qualitive than objective. What exactly is meant by "naive users?" Do you mean patients? How does one define their level of naivete in this case? What exactly does a "naive" person indicate in this instance? Is there any source for this claim? MSTCrow 14:44, Nov 23, 2004 (UTC)
Naive with respect to stimulants, I.E. newly diagnosed. The data is from a published paper listed at www.modafinal.com IIRC. Rich Farmbrough 19:18, 21 Dec 2004 (UTC)
- Yes, "naive" when used in medical papers means a patient not yet exposed to whatever the paper is talking about. In this case it means people who have never before used modafinil. --Bk0 20:12, 21 Dec 2004 (UTC)