Isabella of Burgundy
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Isabella (18 July 1501–19 January 1526), Archduchess of Austria by birth and Queen of Denmark by marriage, was the daughter of Philip I and Joanna of Castile and the sister of Emperor Charles V. She was born at Brussels.
At the age of fourteen, Isabella was married by proxy to King Christian II of Denmark (12 August 1515). Two years later, the Archbishop of Norway was sent to escort her to Copenhagen. The marriage was not a success, as the King had a mistress (known as 'The Dove') in residence, and would not hear of getting rid of her. Besides, he was generally considered to be mad. After he had ninety-four nobles beheaded in the course of a single morning, the nobility turned against him. He was deposed, and imprisoned in a tower, with a dwarf for company.
After that, Isabella and her three children, Hans, Christina and Dorothea, were dependent on the charity of her brother Charles. She died at Gent at the age of twenty-four.
Note: Isabella's daughter was the Christina of Milan made famous in Holbein's portrait, painted when Henry VIII of England was looking for his fourth wife.